Test Code #


CPT Code(s) #


Test Name

Anti-beta 2 Glycoprotein 1 IgG

If Profile, Includes Tests:


Disease Name:

Antiphospholipid Syndrome (APS)

Type of Study:

Serum Studies





Reference Range:

Negative 0-20 SGU
Positve >20 SGU




Assay performed once per week. Report availability is one week from the time of specimen receipt.

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

Beta2-GP1-dependent binding is frequently detected in patients with clinical symptoms of anti-phospholipid syndrome (APS). All three isotypes of anti-_2-GP1 (IgG, IgM, and IgA) have been associated with thrombosis. Approximately 20% of patients who test negative for anticardiolipin antibodies (ACA) will test positive for _2-GP1. Anti-_2-GP1 testing can be useful in the evaluation of patients with positive ACA results and a clinical picture that is not consistent with APS. A negative anti-_2-GP1 result in this context would not support a diagnosis of APS. Anti-_2-GP1 testing can also support the diagnosis of APS in patients with a strong clinical picture for APS with negative Lupus anticoagulant and ACA results.

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