Test Code #
CPT Code(s) #
Anticentromere Antibodies (ACA)
Type of Study:
Negative: < 1:40
Titer & ANA pattern reported on all positives.
Assay performed daily Monday-Friday. Report availability is within 48 hours from the time of specimen receipt.
Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.
Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.
Antibodies to centromere antigens are highly specific for Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia, commonly referred to as CREST syndrome, a limited form of systemic sclerosis (SSc). Centromere antibodies can also occasionally be found in low titers in some other autoimmune variants.