Test Code #

032

CPT Code(s) #

86038, 86225

Test Name

Anticentromere Antibodies (ACA)

If Profile, Includes Tests:

N/A

Disease Name:

CREST

Type of Study:

Serum Studies

Methodology:

Indirect Immunofluorescence

Substrate:

HEp-2

Reference Range:

Negative: < 1:40

Units:

Titer & ANA pattern reported on all positives.

Schedule:

Assay performed daily Monday-Friday. Report availability is within 48 hours from the time of specimen receipt.

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

Antibodies to centromere antigens are highly specific for Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia, commonly referred to as CREST syndrome, a limited form of systemic sclerosis (SSc). Centromere antibodies can also occasionally be found in low titers in some other autoimmune variants.

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