Test Code #
CPT Code(s) #
If Profile, Includes Tests:
Drug Induced LE, SLE, other Connective Tissue Diseases
Type of Study:
Negative <1.0 Units
Weak Positive 1.0-1.5 Units
Moderate Positive 1.6-2.5 Units
Strong Positive >2.5 Units
Assay performed once per week. Report availability is one week from the time of specimen receipt.
Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.
Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.
Antibodies to histone are detected in approximately 30% to 60% of patients with systemic lupus erythematosus (SLE), but their presence in about 95% of patients with drug-induced lupus is more important diagnostically. Drug-induced lupus is primarily caused by procainamide and hydralazine) Anti-histone antibodies also occur in approximately 20% of patients with rheumatoid arthritis.