Test Code #

41

CPT Code(s) #

86235

Test Name

Histone Antibodies

Disease Name:

LE, other Connective Tissue Diseases

Type of Study:

Serum Studies

Methodology:

ELISA

Substrate:

Reference Range:

Negative <1.0 Units
Weak Positive 1.0-1.5 Units
Moderate Positive 1.6-2.5 Units
Strong Positive >2.5 Units

Units:

Units

Schedule:

Assay performed once per week. Report availability is one week from the time of specimen receipt.

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

Antibodies to histone are detected in approximately 30% to 60% of patients with systemic lupus erythematosus (SLE), but their presence in about 95% of patients with drug-induced lupus is more important diagnostically. Drug-induced lupus is primarily caused by procainamide and hydralazine) Anti-histone antibodies also occur in approximately 20% of patients with rheumatoid arthritis.

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