Test Code #
CPT Code(s) #
IgA & IgG Tissue Transglutaminase Antibody
If Profile, Includes Tests:
GSE, Celiac Disease, Dermatitis Herpetiformis
Type of Study:
Fluorescence enzyme immunoassay (FEIA)
• Negative < 7
• Equivocal 7-10
• Positive > 10
Assay performed once every week. Report availability is within one week from the time of specimen receipt
Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.
Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year
IgA anti-endomysium antibodies (EmA), IgA and IgG anti-deamidated gliadin peptides (DGP), and IgA anti-tissue transglutaminase (tTG) antibodies are considered specific and sensitive serologic markers for gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis (DH). Although the IgA isotype of these antibodies usually predominates in celiac disease and dermatitis herpetiformis, individuals may also produce IgG isotypes, particularly if the individual is IgA deficient. The sensitivity and specificity of commercially available IgA tTG ELISA tests for the diagnosis of DH have been reported to range from 42% to 99% and 92% to 100%, respectively.