Test Code #

040

CPT Code(s) #

86235

Test Name

Jo-1 (for Polymyositis & Dermatomyositis)

If Profile, Includes Tests:

N/A

Disease Name:

LE, Dermatomyositis, other Connective Tissue Diseases

Type of Study:

Serum Studies

Methodology:

ELISA

Substrate:

Reference Range:

Negative <20 Units
Weak Positive 20-39 Units
Moderate Positive 40-80 Units
Strong Positive >80 Units

Units:

Units

Schedule:

Assay performed once per week. Report availability is one week from the time of specimen receipt.

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

Jo-1 antibodies are seen in 20-40% of patients with dermatomyositis, polymyositis or mixed PM/DM. The presence of these antibodies may associated with pulmonary involvement in patients with myositis. Antibody titer may fluctuate with disease activity.

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