Test Code #


CPT Code(s) #


Test Name

Native Double Stranded DNA (nDNA) Antibody Titer

If Profile, Includes Tests:


Disease Name:

LE, other Connective Tissue Diseases

Type of Study:

Serum Studies


Indirect Immunofluorescence


Crithidia luciliae Double Stranded DNA Antibody (nDNA) IgG

Reference Range:

Negative: < 1:10




Assay performed daily Monday-Friday. Report availability is within 48 hours from the time of specimen receipt.

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

nDNA are highly specific for systemic lupus erythematosus. The frequency and titer of nDNA antibodies fluctuate with disease activity and tend to disappear with immunosuppressive treatment and during remission.

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