Test Code #

13

CPT Code(s) #

88346, 88350

Test Name

Pemphigus/Pemphigoid Antibody Titer - IgG & IgG4

Disease Name:

Bullous Diseases

Type of Study:

Serum Studies

Methodology:

Indirect Immunofluorescence

Substrate:

Primate Esophagus

Reference Range:

Negative: <1:10

Units:

Titer

Schedule:

Assay performed daily Monday-Friday. Report availability is within 48 hours from the time of specimen receipt

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

The detection of anti-skin (IC and BMZ) antibodies aids in the diagnosis, and sometimes prognosis, of autoimmune bullous diseases including pemphigus, pemphigoid, cicatricial pemphigoid, and epidermolysis bullosa acquisita (EBA). Epithelial intercellular antibodies are diagnostic for pemphigus and occur in over 90% of patients with active forms. Antibodies to basement membrane antigens of stratified squamous epithelium occur in about 70% of active bullous pemphigoid, 50% of EBA and 10% of cicatricial pemphigoid patients.

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