Test Code #


CPT Code(s) #


Test Name

RNP (For SLE, MCTD & Others)

If Profile, Includes Tests:


Disease Name:

LE, other Connective Tissue Diseases

Type of Study:

Serum Studies




Reference Range:

Negative <20 Units
Weak Positive 20-39 Units
Moderate Positive 40-80 Units
Strong Positive >80 Units




Assay performed once per week. Report availability is within one week from the time of specimen receipt.

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

Antibodies to RNP occur in 35-45% of systemic lupus erythematosus patients and in over 95% of patients with mixed connective tissue disease.

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