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Test #

Envoplakin Antibody

CPT Code(s) #


If Profile, Includes Tests:


Disease Name:

Paraneoplastic Pemphigus

Type of Study:

Serum Studies





Reference Range:

Ratio <1.0:Negative
Ratio ≥1.0:Positive




Assay performed once every week. Report availability is within one week from time of specimen receipt.

Specimen Requirements:

Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into red capped tube provided with Beutner Laboratories collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8ºC) up to five days and frozen (-20ºC or lower) up to one year.

Clinical Relevance:

Paraneoplastic pemphigus (PNP) is a life-threatening form of pemphigus that is associated with a neoplasm (e.g., non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Castleman tumor, thymoma, sarcoma, Waldenstrom's macroglobulinemia). Pathogenesis is based on a combination of humoral and cellular autoimmune responses. Circulating autoantibodies are directed against multiple antigens, including predominantly plakins (envoplakin, periplakin, desmoplakin I, desmoplakin II, epiplakin), plectin, Dsg1, Dsg3 and BP230. Due to their high specificity (91-100%), anti-envoplakin autoantibodies are considered an important diagnostic marker for paraneoplastic pemphigus. This ELISA is % sensitive in detecting antibodies to envoplakin in PNP patients.

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